Recently, Fu et al. designed and synthesized two anti-GPC3 ADCs with duocarmycin SA and pyrrolobenzodiazepine, which were named hYP7-DC and hYP7-PC, and demonstrated that these two ADCs had antitumor activity against both GPC3-positive HCC cell lines and xenograft models [143]. This evidence concerns the gene GPC3 and hepatocellular carcinoma.