BSG and hepatocellular carcinoma: In the past, there were pre-clinical studies of the anti-tumor effects of Anti-CD147 ILs-DOX [139], G7mAb-DOX [140], and MetFab-DOX [141] in HCC, as well as phase I/II trial (NCT01631552) of IMMU-132 [142] in solid tumors including HCC.