After activation of the FGFR4 signaling pathway, HCC cells undergo proliferation, EMT, anti-apoptosis, angiogenesis, invasion, and drug resistance through activating four downstream pathways: PI3K/AKT/mTOR, RAS/RAF/MAPK, PLCγ/DAG/PKC, and GSK3β/β-catenin [103].. The gene discussed is FGFR4; the disease is hepatocellular carcinoma.