FGF19 and hepatocellular carcinoma: In a phase I trial (NCT02508467) to escalate and expand doses, fisogatinib (BLU-554) produced a clinical response in FGF19-positive patients with advanced HCC: the ORR per RECIST v1.1 was 17% (11 of 66 patients) in FGF19-positive patients and 0% in the FGF19-negative group; 53% of TRAEs in this study were grade 1/2, which were tolerable.