Then, result from western blot analysis demonstrated that OSBPL5 silence caused an increase of E-cadherin and a decrease of N-cadherin and Vimentin in NSCLC cells (Fig. 2G, Additional file 1: Fig. S1G), suggesting OSBPL5 knockdown impeded EMT process in NSCLC cells. The gene discussed is CDH2; the disease is non-small cell lung carcinoma.