SOD1 and Hepatic failure: We investigated plasma SOD level in all of the patients with HEV-induced liver failure and found a significantly higher SOD concentration in HEV-ALF patients compared with that in heathy controls (355.6 ± 12.72 U/mL vs 164.2 ± 3.82 U/mL, P < 0.01) and HEV-AVH patients (355.6 ± 12.72 U/mL vs 230.3 ± 3.29 U/mL, P < 0.01).