Molecular observations support a crucial role for PROK2 in the pathophysiology of cryptorchidism, whereby impaired PROK2/CHD7/FGFR1/SPRY4 gene expression controlled by the regulators NHLH2, EGR4, and PITX1 induces LH deficiency [2, 3]. This evidence concerns the gene PROK2 and cryptorchidism.