The somatic mutation of eight risk PRGs (CASP4, GPX4, GSDMC, TLR3, NLRP1, PLCG1, IL18, and IRF1) hardly occurred in PAAD samples but were commonly observed in colon adenocarcinoma (COAD) and stomach adenocarcinoma (STAD) ones (Figure 6a). The gene discussed is NLRP1; the disease is pancreatic adenocarcinoma.