The somatic mutation of eight risk PRGs (CASP4, GPX4, GSDMC, TLR3, NLRP1, PLCG1, IL18, and IRF1) hardly occurred in PAAD samples but were commonly observed in colon adenocarcinoma (COAD) and stomach adenocarcinoma (STAD) ones (Figure 6a). Here, IRF1 is linked to colon adenocarcinoma.