To investigate the effects of chitosan on angiogenesis in diabetic wound healing process, we first established the rat model of hyperglycemia and skin injury with chitosan treatment, and performed RNA-seq to study the differential expressed genes in vascular endothelium isolated from granulation, and focused on one candidate up-regulated gene CAV1 as well as the activated Wnt signaling pathway induced by chitosan. Here, CAV1 is linked to Hyperglycemia.