IKZF1 and colorectal carcinoma: We have previously shown that for the methylated biomarkers BCAT1 (branched chain amino acid transaminase 1) and IKZF1 (IKAROS family zinc finger 1), 99% of CRC tissues have detectable methylation in either one or both genes, with 62% of the corresponding plasma samples having detectable levels of the methylated biomarkers [16].