IGF1 and neoplasm: The driver gene analysis was done using Maftools.23 We curated a list of 64 BC related genes with clinical and preclinical therapeutic, prognostic, or diagnostic implications, performing an extensive literature search24 (Supplementary Table S2) representing breast cancer relevant pathways (EGFR/RAF/MEK, IGF-1/PI3K/AKT/mTOR, WNT/NOTCH/Hedgehog/FGF/MET, DNA damage repair, cell cycle, hormone receptor signaling, tumor suppressors, and tumor immunology).