TP53 and neoplasm: The apoptosis inhibitor ARC has been associated with chemotherapy resistance, tumorigenesis, and metastasis in the polyoma middle T-antigen (PyMT) transgenic mouse model of BC.28 It has also been shown to lead to TP53 inactivation in TP53 WT malignancies.29 LOC727993, a non-coding antisense RNA of the gene known as PDYN-AS1, and RNU6ATAC, a small nuclear RNA associated with U12-dependent splicing, have not previously been demonstrated to be involved with tumor biology.