Lebel and colleagues found in 2-5-year olds with PDE, associations of postpartum depression with diffusion in tracts of the superior frontal cortex including the anterior portion of the corona radiata (Lebel et al., 2016); while studies in neonates with prenatal exposure to depression and anxiety found altered MD, RD and AD across the corona radiata (Dean et al., 2018). The gene discussed is ALDH7A1; the disease is Alzheimer disease.