In IBD pathogenesis, the massive infiltration of activated macrophages majorly contribute to the paracellular leakage within the epithelium disturbing intestinal barrier function by the production of pro-inflammatory mediators such as tumor necrosis factor (TNF)-α, IL-1β, IL-6, IL-12, arachidonic acid (AA) metabolites, and reactive oxygen or nitrogen species [7–9]. Here, TNF is linked to inflammatory bowel disease.