IL6 and pulmonary fibrosis: This is supported by reports, showing that type I and III fish collagen peptides decrease the expression of IL-6 and IL-1β in isolated adipocytes [24] and that macrophage collagen receptor signaling is linked to the inhibition of pro-inflammatory macrophage differentiation and altered nitric oxide (NO) and reactive oxygen species (ROS) production in a lung fibrosis context [46].