Interestingly, while Src-ULBR was dispensable for most of the probed phospho-signaling activities, it was required for Src-induced Fyn activation (i.e., pTyr420-Fyn level) and activation of the downstream effectors p42/44 MAPKs (i.e., pThr202/pTyr204 level) in these cancer cells (Fig. 5c and Supplementary Fig. S5). This evidence concerns the gene SRC and cancer.