Several genome-wide association studies indicate two main genetic loci with links to AMD and GA formation: 1q31 and 10q26, which correspond to the complement pathway and high-temperature requirement A serine peptidase 1/age-related maculopathy susceptibility 2 (HtrA1/ARMS2) gene polymorphisms, respectively [19]. The gene discussed is ARMS2; the disease is age-related macular degeneration.