Fetuin-A is a hepatic secretory glycoprotein that on the one hand promotes insulin resistance by inhibiting the insulin receptor tyrosine kinase in skeletal muscle and hepatocytes, serving as an adaptor protein for saturated fatty acids and allowing them to activate Toll-like receptor 4 (TLR4), thereby inducing inflammatory signaling and insulin resistance [1, 2]. This evidence concerns the gene AHSG and Insulin resistance.