In a prospective study assessing factors associated with lower limb calcification progression in T2D, baseline fetuin-A levels were inversely correlated to this progression only in univariate but not in multivariable analyses, potentially because the contribution of fetuin-A was fully captured through the mediator pathway—baseline calcification score—which the authors corrected for in fully adjusted models [35]. The gene discussed is AHSG; the disease is type 2 diabetes mellitus.