we confirmed the specificity of the agonist response by applying c-Met inhibitors (tepotinib, capmatinib, crizotinib, savolitinib, and cabozantinib), a HER1 inhibitor (erlotinib), pan-HER inhibitors (neratinib, ibrutinib, dacomitinib, sapitinib, lapatinib, and poziotinib), and combinations of these therapies using the CELsignia test on patient live tumor cell samples. The gene discussed is EGFR; the disease is neoplasm.