GRSF1 and neoplasm: In addition, a xenograft model in immunodeficient mice showed that tumors derived from MHCC-97H cells with decreased GRSF1 expression resulted in smaller tumor sizes (sh-GRSF1 group) and that YY1 overexpression (sh-GRSF1+ov-YY1 group) promoted tumor growth (p<0.05; Fig. 6A-C).