ICAM1 (Intercellular adhesion molecule-1) in alveolar lung epithelial cells enhances adherence of neutrophils to alveolar lung epithelial cells upon lung inflammation,37 suggesting that the antiviral MDA5/RAVER1 pathway driving ICAM1-mediated lung neutrophil/epithelial interaction is critical in severely affected COVID-19 lungs. This evidence concerns the gene IFIH1 and COVID-19.