In order to understand the importance of LZTFL1 and the MDA5/RAVER1 antiviral pathway in COVID-19 disease severity influenced by the COVID-19 GWAS loci, the expression of LZTFL1 and the MDA5/RAVER1 pathway-related genes were examined in vivo at a single cell level in COVID-19-infected lungs obtained from 5 donors deceased by COVID-19 (age<60) using recently reported snRNA-seq datasets.22 This evidence concerns the gene IFIH1 and COVID-19.