Notably, differential gene expression analysis indicated that MDA5 (IFIH1) was significantly induced 3 days after SARS-CoV-2 experimental infection (3 dpi; Figs. 4c and 4d, Supplementary Fig. S7 and Table S3) and ICAM1 was significantly induced 10 days after the infection in alveolar AT2 lung epithelial cells (10 dpi; Fig. 4e and f, Supplementary Fig. S7 and Table S3), suggesting that the antiviral MDA5/RAVER-ICAM1 pathway is activated in alveolar AT2 lung epithelial cells of SARS-CoV-2-resistant monkeys. The gene discussed is IFIH1; the disease is infection.