In the present study, using CRISPRi and sn/scRNA-seq analyses, we identified LZTFL1 and RAVER1 that are expressed in airway ciliated cells and alveolar AT2 lung epithelial cells, respectively, as genes whose expression is affected by the loci that were identified by GWAS to be associated with COVID-19 severity. This evidence concerns the gene LZTFL1 and COVID-19.