EGFR and glioblastoma: EGFR-directed therapy in glioblastoma has included treatment with the antibody-drug conjugate depatuxizumab mafodotin (Depatux-M) composed of the EGFR immunoglobulin G1 monoclonal antibody depatuxizumab coupled to the tubulin inhibitor monomethyl auristatin F (MMAF).11