APOB is the main apolipoprotein of chylomicrons and low‐density lipoproteins (LDL) and is the ligand for the LDL receptor,35 and the low or absent levels of APOB in plasma usually lead to familial hypobetalipoproteinemia and abetalipoproteinemia.36 This evidence concerns the gene APOB and hypobetalipoproteinemia.