MALT1 was positively related to C‐reactive protein (CRP, p = 0.011), TNF‐α (p = 0.036), IL‐17A (p = 0.023), and Mayo score (p = 0.005) in A‐UC patients, CRP (p = 0.017), erythrocyte sedimentation rate (p = 0.033), TNF‐α (p = 0.004), and Crohn's disease activity index score (p = 0.028) in A‐CD patients. This evidence concerns the gene TNF and Cowden disease.