BSG and neoplasm: Some studies linked high CD147 expression to advanced clinical stages (Huang et al. 2015; Wan and Wu 2012; Zhang et al. 2018) and lymph node metastasis (Feng et al. 2013; Huang et al. 2015; Wan and Wu 2012; Zhang et al. 2018; Zhu et al. 2011), while others reported no association with blood or lymphatic vessel invasion, tumor stage or distant metastasis (Cheng et al. 2006; Huang et al. 2015; Ishibashi et al. 2004).