Numerous previous oncological studies dealt with CD147 due to its consistently high expression levels on the surface of various tumor types, such as malignant melanoma (Hu et al. 2017), colorectal (van der Jagt et al. 2006), breast (Marieb et al. 2004) and esophageal cancer (Cheng et al. 2006; Feng et al. 2013; Ishibashi et al. 2004; Wan and Wu 2012; Zhang et al. 2018; Zhu et al. 2011). This evidence concerns the gene BSG and esophageal cancer.