PICK1 and supranuclear palsy, progressive, 1: Primary tauopathies (i.e., Pick’s disease [PiD], corticobasal degeneration [CBD], and progressive supranuclear palsy [PSP]) produce widespread tau pathology in most cortical layers, but lower layers often accumulate more Pick cells in PiD, ballooned neurons in CBD, and globose tangles in motor cortex of PSP [4– 7, 34, 37, 38, 97, 98].