Interestingly, the analyses on CRC‐based GEO data set also showed it was obviously increased in CD133+ CRC cells as compared to that in carcinoma‐associated fibroblasts, a heterogeneous cell population arised from tumour‐infiltrating mesenchymal stem cells or resting fibroblasts and provide a tumour‐promoting microenvironment for tumour progression and metastasis.54 The gene discussed is PROM1; the disease is colorectal carcinoma.