It was reported that inducing IL‐6/STAT3 inflammatory pathway via silencing claudin‐3 expression promoted CRC malignancy by overactivating Wnt/β‐catenin pathway,59 and IL‐6 could promote the EMT of CRC cells through activating the canonical Wnt/β‐catenin signalling pathway in STAT3/ERK‐dependent.60 Here, STAT3 is linked to colorectal carcinoma.