POU5F1 and colorectal carcinoma: Activating Wnt signalling by MEK inhibitors or overexpression of the heat shock protein molecular chaperone, TRAP1, could induce the plasticity and clonogenicity of CSCs in CRC,49, 50 in turn, overexpression of stemness‐related genes such as Oct4 drives Wnt/β‐catenin activation.51