LRP5 and colorectal carcinoma: Interestingly, we found an obviously positive correlation between the mRNA levels of LRP5 and PROM1 (CD133) (p = 0.015, R = 0.117) through analysing the data on CRC and normal tissues from the same TCGA database (Figure 4E), further confirmed the positive regulation of LRP5 activation on stemness of CRC.