LRP5 and colonic neoplasm: By analysing the GSE34053 data set,33 we further confirmed that LRP5 mRNA level was upregulated in CD133+ CRC cells, compared with that in CD133− ones (p = 0.071) and carcinoma‐associated fibroblasts (p = 0.017) isolated from the same stage II colon cancer patient specimen (Figure 4D).