To validate the association between LRP5 mRNA level and OS or RFS, we mapped the Kaplan‐Meier curves of OS and RFS and no obvious association was found between them, even though it seemed CRC patients with low LRP5 mRNA level had superior OS and RFS compared with those with high LRP5 mRNA level (Figure 2E, F). Here, LRP5 is linked to colorectal carcinoma.