Addition of HGF levels to the basic preoperative model, comprising age, sex, concomitant carcinoma in situ, and clinical stage, improved its discriminatory ability for the prediction of LN metastasis, pT3/T4 disease, and NOC disease by a statistically significant margin as measured by AUC values (+ 7%, + 6%, and + 8%, respectively). Here, HGF is linked to in situ carcinoma.