PKM and malignant colon neoplasm: We found that POU2F1 transcripts were positively correlated with hexokinase 2 (HK2), 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2), ALDOA, pyruvate kinase M1/2 (PKM), lactate dehydrogenase A (LDHA), G6PD, and ribose 5-phosphate isomerase A (RPIA) levels in the colon cancer tissues (Fig. 4A, B).