A special pattern of inflammatory indicators has been detected in the systemic circulation in migraine patients, including increased levels of C-reactive proteins (CRP)79, interleukins (ILs e.g. IL-1 and IL-6)80,81, tumor necrosis factor-alpha (TNF-α) and adhesion molecules (ICAM and VCAM)23,82. This evidence concerns the gene TNF and migraine disorder.