ERBB2 and lung carcinoma: As expected, lower doses are needed for prevention studies (30 mg/kg diet in the MMTV-neu model and 40–80 mg/kg diet in the more aggressive A/J model of lung cancer) than treatment studies (100 mg/kg in the MMTV-Neu model), as early intervention is more amenable to pharmacological intervention than treating late-stage, advanced disease42.