IDH1 and cancer: However, in our meta-analysis, only a relatively low number of DEGs were shared between individual datasets, which can be attributed to the fact that different cancer and non-cancer isogenic disease models and experimental conditions were used as briefly outlined as follows: Using colon carcinoma cells, in which IDH1/2 mutations were inserted via a recombinant adeno-associated virus vector methodology, an epithelial-mesenchymal transition (EMT)-like phenotype and changes in gene expression and cell morphology were observed22.