SPP1 and neoplasm: In contrast, 7 out of 15 proteins including, IL17B (P = 0.0001), IP10 (P = 0.0135), LOX-1 (P < 0.0001), MIG (P < 0.0001), MIP-1d (P < 0.0001), SDC1 (P < 0.0001) and OPN (P < 0.0001) were significantly upregulated in tumour tissues compared to normal (AN and PN) (Table 1).