To validate the downregulation of WIF1, DACT2 and SOSTDC1 in various subtypes of BC, qRT-PCR was performed in breast-cancer derived cell lines: ZR751, MCF7, T47D (ER/PR+ HER2-), SKBR3 (ER/PR- HER+), MDAMB231, MDAMB468 (ER/PR- HER2-) and a non-tumorigenic breast cell line HBL10037. The gene discussed is SOSTDC1; the disease is breast carcinoma.