SPP1 and breast cancer: The markers significantly upregulated in BC relative to controls were FGF1 (P = 0.001), FGF2 (P = 0.001), sFRP3 (P = 0.007), IGF-I (P = 0.001), IL-17B (P = 0.001), IP10 (P = 0.001), LOX-1 (P = 0.0026), MIG (P = 0.0001), MIP1d (P = 0.0001), OPN (P = 0.0237), SYN-1 (P-0.0001), WIF1(P = 0.037) Table 2.