Our morphological findings of the close proximity between α7nAChR-expressing pDCs and cholinergic enteric nerve fibers in the colon of OXZ mice imply that the neural cholinergic regulation of immune responses is mediated via α7nAChRs on immune cells, which is consistent with previous reports13, including our report on DSS colitis model19 and food allergy model11. Here, CHRNA7 is linked to food allergy.