The results of smooth curve and logistic regression showed that after adjusting for gender, age, race, education level, income, HDL, UCR, ALB, waist circumference, ALT, AST, BUN, TC, GGT, smoking, drinking, LDH, TBIL, UA, there was a linear relationship between vitamin D3 and insulin resistance (P for non-linearity = 0.01) There is a negative correlation between vitamin D3 level and insulin resistance (Fig. 2). This evidence concerns the gene GPT and Insulin resistance.