In fact, the HLA-DR molecule encoded by the systemic sclerosis with anti-Topoisomerase 1 antibody (ATASSc)-associated alleles (HLA-DRB1*08:02, HLA-DRB1*11:01 and HLA-DRB1*11:04) or suspected allele (HLA-DRB5*01:02) is reported to have a high binding affinity for the immunodominant peptide of topoisomerase 1 self-protein (residues 349–368)30. The gene discussed is HLA-DRB1; the disease is systemic sclerosis.