Our previous work showed a loss of the HNF1B protein expression in several solid tumours, and thus suggests that HNF1B may act in a tumour suppressive fashion in colorectal carcinoma (CRC)15, clear cell renal carcinoma (ccRCC) and chromophobe renal cell carcinoma16, prostate carcinoma (PC)17, and high-grade serous carcinoma (HGSC)18. Here, HNF1B is linked to pachyonychia congenita.