Given the previous results gained from the same set of large intestine carcinoma samples which showed that the effect of the HNF1B gene promoter methylation and the HNF1B mutation is minor15, we can propose that the decreased HNF1B mRNA expression in the large intestine carcinoma samples is most probably caused by a reduction of the HNF1B transcriptional rate, which is usually directly affected by upstream gene expression regulators. Here, HNF1B is linked to colorectal carcinoma.