When down genes matching depression (from at least 3 datasets) were analyzed in Enrichr, a connection to specific transcription factors was identified and of those, 8 genes were also among the downregulated genes, including NR4A1, NR4A2, NR4A3, EGR1, EGR2, FOSB, JUNB, and FOSL2, suggesting a possible causal link between a subset of transcription factors on depression patterns. This evidence concerns the gene JUNB and major depressive disorder.