Results show that in MDM with increased CATB secretion after HIV infection (p = 0.0209), JWH-133 treatment at 0.5 μM (p = 0.0387) and 1 μM (p = 0.0159) showed a significant decrease in total CATB levels in comparison to HIV-infected untreated control (Supplementary Fig. 3a). The gene discussed is TYRP1; the disease is HIV infectious disease.