AGT and left ventricular hypertrophy: Ang II infusion induced in both Pdzrn3f/f and MCM-Pdzrn3f/f mice development of a left ventricular hypertrophy as shown by an increase in heart-to-body weight ratios compared to both vehicle treated Pdzrn3f/f or MCM-Pdzrn3f/f mice (Fig. 7g).