We then monitored and quantified an increase in glycogen storage in situ by the Fourier Transform Infrared Spectroscopy (FTIR) method in heart tissue sections of mutant mice (Fig. 2h) at two and four weeks of age, suggesting that precocious overexpression of Pdzrn3, during the first weeks of life, can affect CM metabolism which may cause or precede the development of heart failure. This evidence concerns the gene PDZRN3 and heart failure.