Less number of Itga4 (α4) 5TGM1-GFP KO2 cells were detected in the BM than 5TGM1-GFP WT cells after 15 and 30 min of i.v. tumor injection (p = 0.016 and p = 0.043, respectively) (Fig. 3D). Here, ITGA4 is linked to neoplasm.