The multivariate logistic regression analysis showed that operation time [OR 1.011 (95% CI 1.006–1.016, P < 0.001)], preoperative albumin [OR 0.864 (95% CI 0.768–0.972, P = 0.015)] and peroperative globulin [OR 1.192 (95% CI 1.058–1.344, P = 0.004)] were independent predictors of postoperative hypoalbuminemia for patients underwent craniotomy due to tumor (Table 4). The gene discussed is ALB; the disease is neoplasm.