CD274 and neoplasm: We made a correlation analysis of PD-1/PD-L1 level between tumor tissue and peripheral blood, our results showed PD-1 level in tissues was correlated with PD-L1mRNA level in PBMCs (P = 0.0109, Spearman r = − 0.5097, Fig. 4A) and sPD-L1 level (P = 0.0086, Spearman r = − 0.5237, Fig. 4B), Unfortunately, we didn’t find a correlation between PD-L1 level in tumor tissues and soluble PD-L1 level in peripheral blood.