RBFOX binding motifs are found to be co-enriched with MBNL and CELF motifs around the same groups of exons in humans, mice and chickens (Kalsotra et al, 2008; Bland et al, 2010; Merkin et al, 2012), and CELF2 and Rbfox2 co-regulate exons in cardiac tissue that show temporal use preferences, or are altered in hearts of a Type I diabetes mouse model (Gazzara et al, 2017). The gene discussed is CELF2; the disease is type 1 diabetes mellitus.