Rbfox1 also regulates splicing of a MEF2A exon in mouse and zebrafish heart that is mis-spliced in cells from human patients with dilated cardiomyopathy (Gao et al, 2016), and Rbfox1 and Rbfox2 cooperatively regulate splicing of Mef2D during C2C12 differentiation (Runfola et al, 2015). The gene discussed is MEF2D; the disease is dilated cardiomyopathy.