We found that multiple rat models of hypertension; Fawn Hooded Hypertensive, Sabra Hypertensive, and Spontaneously Hypertensive Rat Stroke Prone, also harbor SHR allele at Insr promoter, whereas respective control strains Fawn Hooded Low blood pressure, Sabra Normotensive, and Wistar Kyoto contain BN allele (Fig 4E). The gene discussed is INSR; the disease is Hypertension.