ECE1 and cardiovascular disorder: These 28 genes include Synpo2l, Abhd16a, Ece1, Shroom3 (Fig 2B), and Rbfox2 all of which are implicated in cardiovascular disorders including hypertension in humans (Yasuda et al, 2007; Nutter et al, 2016; Xu et al, 2018; Durbin et al, 2020; Clausen et al, 2021).