CCL4 and congenital rubella syndrome: In addition to clinical markers of inflammation, we also found statistically significant declines in cytokines correlated with severity of CRS and ICANS including IL-1a, IL-15, CCL-3, CCL-4, and IL-6.11 23 24 Even though statistically not significant, a trend toward a more pronounced reduction of inflammatory cytokines could be observed in patients with peak ICANS 3–4 and a clinical response to anakinra, in comparison to those patients with ICANS 3–4 without a clinical response to anakinra.