TGFB1 and cutaneous tuberculosis: The suppressive mediation of Treg cells occurs mainly through the secretion of the immunosuppressive cytokine TGF-β, which has an anti-inflammatory effect.31, 32, 33 In patients with cutaneous tuberculosis, Treg cells produce a significant amount of TGF-β, which plays an important role in CD4+, CD25+ Treg expansion and also inhibits Th17 cell polarization.22