CCL2 and early-onset autosomal dominant Alzheimer disease: Contrary to our findings, the first human study exploring longitudinal associations of MCP-1 with Alzheimer’s disease (AD) progression showed that CSF but not plasma MCP-1 was elevated in prodromal AD compared to non-prodromal AD individuals with mild-cognitive impairment (MCI), and that CSF MCP-1 was associated to greater cognitive decline in subjects developing AD [34].