ZFP64 and neoplasm: Moreover, MAPK and PI3K signaling were responsible for the gain of the stem-like phenotype of GC cells, and individual inhibitors of MAPK and PI3K signaling partially sensitized GC cells to nab-paclitaxel therapy both in vitro and in vivo, while OTX008 reversed drug resistance and the immunosuppressive tumor microenvironment induced by elevated ZFP64 expression in vivo.