ZFP64 and hepatocellular carcinoma: In fact, several high-throughput analyses indicated that ZFP64 dysregulation might play a vital role in cancer development; for example, a proteomic analysis revealed the upregulation of ZFP64 in samples of liver metastasis of colorectal carcinoma compared to primary cancer samples, and high expression (more than median) of ZFP64 correlated significantly with vascular invasion and potentially represents a prognostic marker of metastasis and death in patients with hepatocellular carcinoma [26, 27].