Though up to now SOX11 has not been found to be the downstream of ASCL1 in pulmonary NE cell differentiation, NE differentiation of prostate cancer cells is suggested to be partially mediated by SOX11, [27] and a recent paper shows that SOX11 mRNA is upregulated in pulmonary HG-NECs [19]. This evidence concerns the gene SOX11 and Familial prostate cancer.