SOX11 and leukoencephalopathy with calcifications and cysts: As demonstrated in Fig. 1 and Table 1, the positivity of SOX11 in SCLCs and LCNECsupdate (4 SOX11+ LCC-NEMs were regrouped into LCNECs) were 64% (127/199) and 43% (27/63), that were similar to INSM1 (SCLC: 75%, 59/79, p > 0.05; LCNEC: 53%, 21/40, p > 0.05) and CGA (SCLC: 70%, 136/193, p > 0.05; LCNEC: 57%, 36/63, p > 0.05), and less than SYN (SCLC: 82%, 158/193, p < 0.0001; LCNEC: 76%, 48/63, p < 0.001) and CD56 (SCLC: 88%, 169/191, p < 0.0001; LCNEC: 73%, 44/60, p < 0.001).