However, in practice, ambiguous morphology due to crush artifacts is not rare and positivity of SOX11 in 7 of 18 SYN−/CGA−/CD56− SCLCs and 3 of 8 SYN−/CGA−/CD56−/INSM1− SCLCs provide evidence on the confidential diagnosis of SCLC. This evidence concerns the gene INSM1 and small cell lung carcinoma.