Univariate analysis showed that age, baseline CA199 level, CEA level, total bilirubin level, albumin level, NLR, weight loss, peripancreatic invasion, operative procedure, tumor size, lymph node metastasis, hepatic metastasis, number of distant organ metastasis, and postoperative adjuvant chemotherapy were the relevant factors affecting the prognosis of the PC group (P<0.05). The gene discussed is CEACAM5; the disease is pachyonychia congenita.