The gluconeogenic enzyme fructose-1,6-bisphosphatase 1 (FBP1), one of the related-limiting enzymes in gluconeogenesis, exerts crucial function switching from glycolysis to oxidative phosphorylation (OXPHOS), which is necessary for tumour malignancy, blocking cancer progression via the Snail-FBP1 axis [129, 130]. Here, FBP1 is linked to cancer.