Despite sharing the same sequences with the host PLCE1, circPLCE1-411 demonstrates a distinct capability to suppress colorectal cancer cell proliferation and migration via its interaction with the ATP-binding domain of HSP90α to accelerate the dissociation of RPS3 from the HSP90α/RPS3 complex, leading to HSP70-induced ubiquitin-dependent degradation of RPS3 and the suppression of NF-κB nuclear translocation and activation [61]. This evidence concerns the gene HSP90AA1 and colorectal cancer.