Moreover, it acts as a partner by binding to peroxiredoxin 2 (PRDX2) to induce an E3 ligase of the SCF ubiquitination complex for RBX1-mediated ubiquitination and degradation of PRDX2 and inactivation of its downstream signalling pathways, hampering the proliferation and invasion of GC [60, 125]. The gene discussed is PRDX2; the disease is gastric cancer.