In our previous studies, Notch inhibition significantly impaired cell growth of c-CSC compared to p-CSC, Besides, p-CSC are more refractory to anti-EGFR targeting either alone or in combination with the anti-Notch1 drug compared to c-CSC [3], suggesting that p-CSC possess a different genetic background which confers them resistance to the anti-tumor agents [3]. Here, EGFR is linked to neoplasm.