By comparative analysis, we identified common gene single nucleotide variants (SNV) in all GBM c-CSC, and p-CSC in the following genes: TP73, PDE4DIP, FN1, KMT2C, MUC6, CREB3L1, GSE1, APC2, and MUC16. The gene discussed is CREB3L1; the disease is glioblastoma.