TGFB1 and osteosarcoma: However, because high cholesterol can also inhibit the TGF-β / Wnt pathway [54, 55], which is essential for normal osteogenesis, it may indicate that patients with hyperlipidemia may have a higher or lower risk of osteosarcoma, but both conjectures lack the support of experimental results and clinical statistics at this stage; therefore, new studies are urgently needed.