RNPC3 and infection: A study by Gonzalez-Quintial et al. [68] observed that a single dose of crystalline silica in C57BL/6 mice did not induce an autoantibody response, while in combination with an infection with the model murine pathogen lymphocytic choriomeningitis virus (LCMV) autoantibodies to several nuclear self-antigens including chromatin, RNP and Sm in serum could be observed.