Rajasinghe et al. [64] observed robust IgG and IgM autoantibody responses against lupus-associated autoantigens including DNA, histones, ribonucleoprotein, Smith antigen, Ro/SSA, La/SSB, and complement one week after crystalline silica exposure in BALF of NZBWF1 mice. This evidence concerns the gene CALR and systemic lupus erythematosus.